Trying to reach a worldwide audience? A content delivery network (CDN) is he way to go. The whole idea is to push your content from a node closest to your audience. This blog is pushed out of CloudFlare which delivers it worldwide with the least amount of network hops.
This world map shows this cdn’s node locations in major cities. If your audience is closest to one of these nodes, they will be better served by the cdn, rather than a fixed location.